Based on these and other preclinical data, Memogain may represent an advantageous drug treatment for Alzheimer's disease, combining much lesser gastrointestinal side effects and considerably higher potency in enhancing cognition, as compared to presently available drugs.
In the ferret, dramatically reduced emetic and behavioral responses were observed when Memogain was administered instead of galantamine.
However, these drugs have some disadvantages such as hepatotoxicity and persistent nausea (Sharma, 2019). In animal models of drug-induced amnesia, Memogain produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. Acetylcholinesterase inhibitors have been utilized to treat Alzheimer-induced amnesia and cognitive decline (Kumar and Singh, 2015). In the brain, Memogain is enzymatically cleaved to galantamine, thereby regaining its pharmacological activity as a cholinergic enhancer. They may order imaging tests, such as an MRI (Magnetic Resonance Imaging) or computed tomography (CT) scan to look for signs of brain damage, such as brain tumors or stroke. People with amnesia cannot remember past experiences, form new memories, or both.
Some amnesia does not need treatment for they last for a while like severer head injury that may last for a month and trauma last for a minute or an hour. Memogain has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. To determine the cause of amnesia, your provider may order blood tests to check vitamin B1 levels, B12 levels and thyroid hormones. Ginkgo ketoester tablets (GT) and donepezil were a clinically used combination for the treatment of Alzheimers disease (AD). Table of Contents View All Misconceptions Stages of Memory Types Causes Treatment Amnesia is a memory disorder. This is a type of amnesia which occur when one takes specific drugs that rubs off the memory which is just temporary memory loss. Memogain (Gln-1062) is an inactive pro-drug of galantamine, the latter being a plant alkaloid approved for the treatment of mild to moderate Alzheimer's disease.
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